| Gonzaga | | | | | | | | | | Baylor |
March 20, 2021  98- 55  | March 19, 2021  79- 55  |
| Gonzaga | Baylor |
March 22, 2021 87- 71  Recap | March 21, 2021 76- 63  Recap |
| Norfolk St. | Hartford |
| | Gonzaga | Baylor | |
| Oklahoma | March 28, 2021 83- 65  Recap | March 27, 2021 62- 51  Recap | North Carolina |
March 20, 2021 72- 68  Recap | March 19, 2021  62- 85 |
| Oklahoma | Wisconsin |
| | |
| Missouri | Wisconsin |
| | Gonzaga | Baylor | |
| Creighton | March 30, 2021 85- 66  Recap | March 29, 2021 81- 72  Recap | Villanova |
March 20, 2021 63- 62  Recap | March 19, 2021 73- 63  Recap |
| Creighton | Villanova |
March 22, 2021 72- 58  Recap | March 21, 2021 84- 61  Recap |
| UCSB | Winthrop |
| | Creighton | Villanova | |
| Virginia | | | Purdue |
March 20, 2021  58- 62 | March 19, 2021  69- 78 |
| Ohio | North Texas |
| | |
| Ohio | North Texas |
| | Gonzaga | Baylor | |
| USC | April 3, 2021 93- 90  Recap | April 3, 2021 78- 59  Recap | Texas Tech |
March 20, 2021 72- 56  Recap | March 19, 2021  65- 53  |
| USC | Texas Tech |
March 22, 2021 85- 51  Recap | March 21, 2021 66- 68 Recap |
| Drake | Utah St. |
| | USC | Arkansas | |
| Kansas | March 28, 2021 82- 68  Recap | March 27, 2021 72- 70  Recap | Arkansas |
March 20, 2021 93- 84  Recap | March 19, 2021 85- 68  Recap |
| Kansas | Arkansas |
| | |
| Eastern Wash. | Colgate |
| | USC | Gonzaga | Arkansas | |
| Oregon | | April 5, 2021 70- 86 Recap | | Florida |
March 20, 2021 Recap | March 19, 2021  75- 70  |
| Oregon | Florida |
March 22, 2021 95- 80  Recap | March 21, 2021 78- 81 Recap |
| VCU | Virginia Tech |
| | Oregon | Oral Roberts | |
| Iowa | | | Ohio St. |
March 20, 2021 86- 74  Recap | March 19, 2021  72- 75 |
| Iowa | Oral Roberts |
| | |
| Grand Canyon | Oral Roberts |
| | |
| Michigan | Illinois |
March 20, 2021  82- 66  | March 19, 2021  78- 49  |
| Michigan | Illinois |
March 22, 2021 86- 78  Recap | March 21, 2021 58- 71  Recap |
| Texas Southern | Drexel |
| | Michigan | Loyola Chicago | |
| LSU | March 28, 2021 76- 58  Recap | March 27, 2021 58- 65  Recap | Loyola Chicago |
March 20, 2021 76- 61  Recap | March 19, 2021 71- 60  Recap |
| LSU | Loyola Chicago |
| | |
| St. Bonaventure | Georgia Tech |
| | Michigan | Baylor | Oregon St. | |
| Colorado | March 30, 2021 49- 51 Recap | | March 29, 2021 61- 67 Recap | Tennessee |
March 20, 2021  96- 73  | March 19, 2021  56- 70 |
| Colorado | Oregon St. |
March 22, 2021 53- 71 Recap | March 21, 2021 80- 70  Recap |
| Georgetown | Oregon St. |
| | Florida St. | Oregon St. | |
| Florida St. | | | Oklahoma St. |
March 20, 2021 64- 54  Recap | March 19, 2021 69- 60  Recap |
| Florida St. | Oklahoma St. |
| | |
| UNC Greensboro | Liberty |
| | UCLA | Houston | |
| BYU | | | San Diego St. |
March 20, 2021  62- 73 | March 19, 2021  62- 78  |
| UCLA | Syracuse |
March 22, 2021 67- 47  Recap | March 21, 2021 75- 72  Recap |
| UCLA | Syracuse |
| | UCLA | Syracuse | |
| Texas | March 28, 2021 88- 78  Recap | March 27, 2021 46- 62 Recap | West Virginia |
March 20, 2021  52- 53 | March 19, 2021 84- 67  Recap |
| Abilene Christian | West Virginia |
| | |
| Abilene Christian | Morehead St. |
| | UCLA | Houston | |
| UConn | | | Clemson |
March 20, 2021  54- 63  | March 19, 2021  56- 60  |
| Maryland | Rutgers |
March 22, 2021 77- 96 Recap | March 21, 2021 60- 63 Recap |
| Maryland | Rutgers |
| | Alabama | Houston | |
| Alabama | | | Houston |
March 20, 2021 68- 55  Recap | March 19, 2021 87- 56  Recap |
| Alabama | Houston |
| | |
| Iona | Cleveland St. |
